https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45103 Wed 26 Oct 2022 13:14:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45083 cis-regulatory elements and their associated trans-acting factors. Where these components aggregate in promoters and enhancers, they are able to cooperate to modulate chromatin structure and support the engagement in long-range 3D superstructures that shape the dynamics of a cell's genomic architecture. Recently, the term 'super-enhancer' has been introduced to describe a hyper-active regulatory domain comprising a complex array of sequence elements that work together to control the key gene networks involved in cell identity. Here, we survey the unique characteristics of super-enhancers compared to other enhancer types and summarize the recent advances in our understanding of their biological role in gene regulation. In particular, we discuss their capacity to attract the formation of phase-separated condensates, and capacity to generate three-dimensional genome structures that precisely activate their target genes. We also propose a multi-stage transition model to explain the evolutionary pressure driving the development of super-enhancers in complex organisms, and highlight the potential for involvement in tumorigenesis. Finally, we discuss more broadly the role of super-enhancers in human health disorders and related potential in therapeutic interventions.]]> Wed 26 Oct 2022 12:02:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51035 Wed 16 Aug 2023 10:17:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46016 Wed 09 Nov 2022 08:31:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47678 EMBO Reports, Lackinger et al demonstrate that a large cluster of miRNAs, that emerged in placental mammals, functions as a repressor of social behaviour. This discovery has significant implications for our understanding of the brain, behaviour and in particular psychiatric syndromes, which have been shown to display alterations of these molecules.]]> Tue 24 Jan 2023 16:30:14 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50980 Mon 14 Aug 2023 15:24:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51705 Fri 15 Sep 2023 14:03:12 AEST ]]>